Hypothesis of the Role of Magnesium Upon COVID-19 Infection and Disease Onset

Our main objective is to test our hypothesis that expression of viral ion channels encoded by SARS-CoV-2 genes in the heart increases the risk of sudden cardiac death and cardiac damage in COVID-19 patients with pre-existing cardiovascular disease, especially with hypertension, which is reported as a most frequent cardiovascular risk factor in COVID-19 cohorts, Moreover, recommend test the efficacy of clinically approved magnesium supplementation for preventing sudden cardiac death in COVID-19 with pre-existing hypertension. © 2022 American Institute of Physics Inc.. All rights reserved.

The Risk of Up Normal Values of Two Parameters Obesity and Vitamin D in Incidence of Coronavirus Disease-19 Among Iraqi Patients

The new epidemic of coronavirus disease-19 outbreak has caused rapid morbidity and mortality rates worldwide, and health parameters have been proposed to influence disease progression. Among these parameters are index of body mass (BMI) and D vitamin. 86 patients with same number of control were studied(case-control) to find the relationship between the BMI, vitamin D and risk of COVID-19. Vitamin D (25-hydroxyvitamin D) serum level was estimated by ELISA. Results revealed that the age mean value was elevated significantly in cases compared to normal persons, and 50% of patients were 50 years of age or older. patients BMI were higher significantly in comparison with controls, and most of patients were overweight/obese (76.7%). The Vitamin D level decreased in patients significantly compared to control, and most of patients were severely-deficient (75.6%). Logistic-regression-analysis depicted a high risk of COVID-19 in obese cases (OR= 26.39;95% interval of confidence [CI]: 7.02-99.24;p < 0.001), and in patients with severe deficient in vitamin D (OR = 13.34;95% CI: 6.32-28.19;< 0.001). Moreover, overweight/obese patients severely deficient in vitamin D were at high risk of developing COVID-19 infection (OR = 230.55;95% CI: 43.98-1208.67;p < 0.001). Curve analysis of ROC(Receiver-operating-characteristic) showed that BMI and vitamin D occupied under curve significant area (0.770 and 0.864, respectively). In conclusions, the study indicated that individuals who were overweight/obese and severely deficient in vitamin D were more susceptible to develop COVID-19. © 2022 American Institute of Physics Inc.. All rights reserved.